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Halo 3 was made a free download for Xbox Live Gold subscribers through the \"Games with Gold\" program in October 2013.[63] It became playable on the Xbox One via backwards compatibility in 2017.[64] An Xbox One-native version of the game, presenting the graphics at 1080p and 60 frames per second, was included as part of Halo: The Master Chief Collection for the Xbox One in 2014. Halo 3 was re-released again as part of the Windows version of The Master Chief Collection in 2020.[65]
Halo 3 supports multiplayer map downloadable content as well as game updates via Xbox Live.[66] The first three post-release multiplayer maps, \"Standoff\", \"Rat's Nest\", and \"Foundry\", were released as a pack on December 11, 2007, collectively known as the \"Heroic Map Pack\".[67] A second group of three maps including a remake of Halo 2 map \"Lockout\", titled \"Blackout\", a new map \"Ghost Town\" and a remake of Halo: Combat Evolved map \"Sidewinder\", titled \"Avalanche\" were bundled as the \"Legendary Map Pack\", on April 15, 2008.[68] These maps introduced visual filters to the Forge pallet, which change the way the maps look.[69] A remake of the Halo: Combat Evolved map \"Chill Out\", titled \"Cold Storage\", was released as a free download on \"Bungie Day\", July 7, 2008.[70] The third multiplayer map pack, titled the \"Mythic Map Pack\" and consisting of the maps \"Orbital\", \"Assembly\", and \"Sandbox\", was included with the Limited Collectors Edition of Halo Wars.[71] The map pack was released over the Xbox Live Marketplace on April 9, 2009.[72] The fourth and final multiplayer map pack, \"Mythic II Map Pack\", was released on February 2, 2010. The map pack includes the three new maps from Halo 3: ODST: \"Citadel\", \"Longshore\", and a remake of Halo 2 map \"Midship\", titled \"Heretic\".[73]
Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines. Similar to IL-1β, IL-18 is synthesized as an inactive precursor requiring processing by caspase-1 into an active cytokine but unlike IL-1β, the IL-18 precursor is constitutively present in nearly all cells in healthy humans and animals. The activity of IL-18 is balanced by the presence of a high affinity, naturally occurring IL-18 binding protein (IL-18BP). In humans, increased disease severity can be associated with an imbalance of IL-18 to IL-18BP such that the levels of free IL-18 are elevated in the circulation. Increasing number of studies have expanded the role of IL-18 in mediating inflammation in animal models of disease using the IL-18BP, IL-18-deficient mice, neutralization of IL-18, or deficiency in the IL-18 receptor alpha chain. A role for IL-18 has been implicated in several autoimmune diseases, myocardial function, emphysema, metabolic syndromes, psoriasis, inflammatory bowel disease, hemophagocytic syndromes, macrophage activation syndrome, sepsis, and acute kidney injury, although in some models of disease, IL-18 is protective. IL-18 plays a major role in the production of interferon-γ from T-cells and natural killer cells. The IL-18BP has been used safely in humans and clinical trials of IL-18BP as well as neutralizing anti-IL-18 antibodies are in clinical trials. This review updates the biology of IL-18 as well as its role in human disease.
Dead Space 2: Severed is a downloadable content that expands the single-player campaign of Dead Space 2.[7] It contains two stand-alone chapters starring Gabe Weller and Lexine Murdoch from Dead Space: Extraction and runs in parallel to Isaac's story in Dead Space 2.[7] The player takes control of Gabe, currently stationed on the Sprawl as a security guard. Dead Space 2: Severed was released on March 1, 2011 on Xbox LIVE and PlayStation Network for 560 Microsoft points or $6.99.
On the 24 of February 2011, an official patch was released for PC, Giving players access to the Supernova, Hazard and Martial Law Packs for free, as well as key-binding and numerous bug fixes.[8]
As an added bonus, those who pre-ordered the game from certain retailers in North America, JB HI-FI in Australia and GAME in the UK will receive a code for a free download of Dead Space: Ignition and an in-game Rivet Gun, downloadable from the PlayStation Store or Xbox LIVE.[9]
Mass Effect: Genesis is an optional, interactive DLC comic that is enabled after completing the Prologue - Save Joker Mission. It was introduced in 2011 for the PlayStation 3 port of Mass Effect 2, since at the time Mass Effect 1 was not available on that system. It was later made available for Xbox 360 and PC players as well, since skipping Mass Effect 1 is rather common for new players of the Trilogy, and is included for free in the Legendary Edition.
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