Go Guy Plus Eiji 19 20 [2021]
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The FA Cup always delivers shocks and plenty of Premier League clubs had tricky tasks facing them in the fourth round. One still has one, in fact.After Aston Villa, Newcastle, Nottingham Forest, and Bournemouth were all knocked out by lower league opponents in round three, plus Everton, Chelsea, Crystal Palace, Arsenal, and Brentford knocked out by fellow Premier League sides, there were only 10 top-flight teams left in the competition.
Haaland also could topple the record for goal involvements (goals plus assists) in a single season, including beating the 42-game record. Alan Shearer put up 47 over 42, while Thierry Henry holds the 38-game record with 44.
Background: In patients with heavily treated metastatic colorectal cancer, TAS-102-a combination of trifluridine and tipiracil-has shown a significant overall survival benefit compared with placebo. In preclinical models, TAS-102 plus bevacizumab has shown enhanced activity against colorectal cancer xenografts compared with that for either drug alone. In this phase 1/2 study, we assessed the activity and safety of TAS-102 plus bevacizumab.
Methods: We did this investigator-initiated, open-label, single-arm, multicentre, phase 1/2 trial of TAS-102 plus bevacizumab in four cancer centres in Japan. Eligible patients were aged 20 years or older; had histologically confirmed unresectable, metastatic colorectal adenocarcinoma; were refractory or intolerant to fluoropyrimidine, irinotecan, oxaliplatin, anti-VEGF therapy, and anti-EGFR therapy (for tumours with wild-type KRAS); and had no previous treatment with regorafenib. Patients had to have an Eastern Cooperative Oncology Group performance status of 0 or 1. Using a dose de-escalation design in phase 1, the recommended phase 2 dose (RP2D) was determined for TAS-102 (35 mg/m2 given orally twice daily on days 1-5 and 8-12 in a 28-day cycle for level 1) plus bevacizumab (5 mg/kg, administered by intravenous infusion for 30 min every 2 weeks). In phase 2, patients received the RP2D. The primary endpoint was centrally assessed progression-free survival at 16 weeks, analysed in the first 21 patients to be enrolled and treated with the RP2D who had at least one imaging assessment. This study is completed and registered with the University Hospital Medical Information Network, number UMIN000012883.
Interpretation: TAS-102 plus bevacizumab has promising activity with manageable safety, suggesting that this combination might become a potential treatment option for patients with metastatic colorectal cancer in a refractory setting.
Muto Ashirogi, AKA Moritaka Mashiro and Akito Takagi, whom Eiji is a fan of and considers his rival in Jump. He always addresses them as Ashirogi Sensei when together, or their name plus \"sensei\" if one of them is missing. As their competitor in Jump, Eiji is always trying to outdo them and encourage them at the same time, maintaining a healthy rivalry with Ashirogi.
If V and y are constant, then any increase in M must cause an increase in P. More typically, of course, V and y are changing but in somewhat predictable ways. A simple algebraic proof shows that the percentage change in M plus the percentage change in V must approximately equal the percentage change in P plus the percentage change in y. So, for example, if real GDP is growing at 3 percent per year and V is growing at 1 percent per year, then a 4 percent annual growth in the money supply will lead to an inflation rate of 2 percent. (4 + 1 = 2 + 3.)
We're not really sure. Link seems to be in it, Zelda's in it (for a bit, at least), plus a dead guy that looks like Ganondorf, and a Hyrule that has been torn up, with many new islands being launched into the sky by... something. Something bad, presumably. And there are tears... of the... uh... kingdom. Whatever that means. 153554b96e
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